Medherant has an experienced team of scientists with excellent knowledge of polymer adhesives, transdermal delivery formulation and analytical methodologies. They are dedicated to delivering innovative transdermal delivery solutions for existing drugs using our proprietary TEPI® Patch technology.
Our R&D capabilities include
Rapid Compatibility Evaluation
We quickly assess a drug’s compatibility with the TEPI® Patch technology by producing a range of formulations and conducting a series of tests. This enables an early go/no-go decision on the feasibility of transdermal drug delivery.
Formulation Development
Leveraging our extensive knowledge of skin biology and transdermal delivery, we formulate TEPI® Patches using a large library of pharmaceutically acceptable excipients, including those used to enhance permeation of the drug through the skin.
Excipient Selection
We investigate a wide range of approved excipients both individually and in combinations, some of which may be complex, in order to achieve the target permeation profile using human skin ex vivo.
Patch Prototyping and Manufacture
Our team performs experiments at multiple scales to develop TEPI® Patch prototypes and refine manufacturing processes using our in-house pilot plant.
Analytical Expertise
Using HPLC and other quantitative analyses, we measure drug uniformity, release, permeation and degradation at the temperatures required for patch manufacture.
In vitro Diffusion Assay
We rapidly evaluate drug flux from prototype patches using either Strat-M (a skin mimic) or human skin. Large scale studies enable us to identify the optimal formulation within just a few months.
Product Testing
Our analytical team use industry standard techniques to develop product-specific tests. We analyse the results to confirm that the patch meets the target product profile.
Development of New Adhesives
Our TEPI technology is based on a novel adhesive platform developed by our scientists. We offer a range of different adhesive options to ensure the best fit for each patch product.